Hall Biosketch

BIOGRAPHICAL SKETCH

NAME: John E. Hall, Ph.D.
eRA COMMONS USER NAME (credential, e.g., agency login): johnehall
POSITION TITLE: Arthur C. Guyton Professor & Chair; Director, Mississippi Center for Obesity Research
EDUCATION/TRAINING 

Personal Statement

My major research contributions have been in the general fields of cardiovascular and renal diseases, mechanisms of hypertension and target organ injury, obesity and metabolic disorders. Current research in our laboratory is focused on mechanisms of obesity and cardiorenal injury, heart failure, central nervous system mechanisms of obesity-induced hypertension, and how the molecular signaling pathways that regulate appetite, energy expenditure and sympathetic activity are altered in obesity. Our lab uses genetic, molecular, integrative physiological, and translational approaches in our research studies and we have extensive experience in cardiovascular, renal and metabolic phenotyping. My contributions to science include 24 books and >630 scientific publications.  My research has been funded by NIH since 1975. I have served as PI of the NIH/NIGMS-funded Center for Biomedical Research Excellence (COBRE) grant (P20GM104357) for the past 10 years and served as PI of a NHLBI-funded Program Project grant (P01HL-51971) for 30 years. I also currently serve as Professional Development Core Director of a NIH/NIGMS funded Center for Clinical and Translational Research (U54GM115428) and co-investigator of 3 NIH R01 grants (R01DK121748, R01DK121411 and R01HL163076). I also receive research funding as an endowed chair and philanthropic support as Director of the Mississippi Center for Obesity Research. I have mentored over 150 postdoctoral fellows, graduate students, medical students and undergraduate students, as well as many new faculty investigators. At least 7 of my trainees have become chairs/directors of departments, two have become Dean/Vice Dean of Graduate School /Academic Affairs, and many are productive researchers at academic institutions. Thus, I have the expertise and experience to effectively serve a Director/PI of the COBRE and to lead this multidisciplinary “Team Science” group of investigators.

Positions, Scientific Appointments, and Honors

Professional Experience (Selected)

2013-Present             Founding Director, Cardiorenal and Metabolic Diseases Research Center

2010-Present             Founding Director, Mississippi Center for Obesity Research

2005-2013                 Associate Vice Chancellor for Research

1996-2008                 Founding Director, Center of Excellence in Cardiovascular-Renal Research

1989-Present              Arthur Guyton Endowed Professor and Chair, Physiology Dept., Univ. of Mississippi Med. Ctr.

1982-88                     Professor, Physiology Dept., Univ. of Mississippi Med. Ctr.

1980-93                     Director of Graduate Program, Physiol. Dept., Univ. of Mississippi Med. Ctr.

1979-82                     Assoc. Prof., Physiology Dept., Univ of Mississippi Med. Ctr.

1976-79                     Assistant Professor, Physiology Department, University of Mississippi Medical Center

Honors, Professional Society Leadership, Editorships (Selected)

2019                      Arthur C. Guyton Award and Lecture, Association of Chairs of Departments of Physiology

2016-2017             Carl G. Evers Basic Science Professor of the Year, selected by medical students of the University of Mississippi Medical Center                   

2016                      Ray G. Daggs Award for distinguished long-term service to the science of physiology, American Physiological Society

2016                      The Clifford V. and Drusilla R. Harding Lecture, Oakland University

2016                      Thomas G. Muldoon Memorial Lectureship, Medical College of Georgia, Augusta University

2016                      Scholar Award, Distinguished Lecture Series, Texas A & M University

2015                      Distinguished Service Award, Association of Chairs of Departments of Physiology

2015-2016             Carl G. Evers “All Star” Professor, selected by medical students of UMMC

2015                      Award of Meritorious Achievement of the American Heart Association

2015                      Visitante Ilustre de Facultad de Medicina de la Universidad Nacional de Tucuman, Argentina

2015                      John D. Bower M.D. Distinguished Lectureship, University of Virginia School of Medicine

2015                      Joy Goodwin Distinguished Lectureship, Auburn University

2014                      International Society of Hypertension Distinguished Member Award

2014                      Southeastern Conference Professor of the Year Award

2013-1014             SEC Faculty Achievement Award

2013                      Kent State University Distinguished Alumnus Award and Hall of Fame

2013                      Sir George Pickering Lecture, British Hypertension Society

2013                      Doctor Honoris Causa, Grigore T. Popa Universitatea De Medicina Si Farmacie, Romania

2012                      International Society of Hypertension Franz Volhard Award for Outstanding Research

2012                      Excellence Award and inducted into Mississippi Innovators Hall of Fame

2010                      Joseph Dvorkin Memorial Lecture, University of Alberta Cardiovascular Research Centre

2010                      James O. Davis Distinguished Lecture, University of Missouri at Columbia, College of Medicine

2009                      Lifetime Achievement Award, Inter-American Society of Hypertension

2007                      Presidential Lecture, Canadian Society of Hypertension

2006                      Mayerson-DiLuzio Memorial Lecture, Tulane School of Medicine

2007                      Inducted into Norman C. Nelson Order for teaching excellence UMMC

2006                      British Medical Association Book Competition Award, Basic and Clinical Sciences, for Textbook of Medical Physiology

2005                      Distinguished Achievement Award, AHA, Council for High Blood Pressure Research

2005                      A. Ross McIntyre Award, University of Nebraska

2005-2006             Carl G. Evers “All Star” Professor, selected by medical students of UMMC

2005                      Executive Council, Treasurer, International Union of Physiological Sciences

2003                      Lifetime Achievement Award, COSEHC

2002                      Novartis Award for Hypertension Research, Council for High Blood Pressure Research, AHA

2002-2012             Editor-in-Chief, Hypertension, American Heart Association

2002-2010             Executive Council, International Society of Hypertension

2001-2003             President, Inter-American Society of Hypertension

2000                      Richard Bright Award, American Society of Hypertension

2000                      Burroughs Welcome Fund Professor in Basic Medical Sciences

2000                      National Board of Directors, AHA

2000-2001             Chair, Committee of Scientific Councils, Science Advisory and Coordinating Committee

2000-2003             President-Elect, President, Past-President, American Physiological Society

1998                      Ernest H. Starling Distinguished Lectureship and Award, American Physiological Society

1998                      Robert Tigerstedt Award for Research Excellence, International Society of Hypertension

1997-2000             Chair of the Section Advisory Committee, American Physiological Society

1996-2002             Chair-Elect, Chair, Past-Chair, Council for High Blood Pressure Research, AHA

1996-2006             Billy S. Guyton Distinguished Professor, University of Mississippi

1996                      Special Research Achievement Award, American Heart Assoc., MS

1996-2002             Editor-in-Chief, Am. J. Physiol.: Regulatory, Integrative, and Comparative Physiol.

1994-2001             Executive Council, American Society of Hypertension

1994-2003             Executive Council, AHA Council for High Blood Pressure Research

1993-1996             Frederick A.P. Barnard Distinguished Professor, University of Mississippi

1992                      Lewis K. Dahl Award, American Heart Association

1991, 1997-2003   Executive Council, The American Physiology Society

1991-1994             Chair, Water and Electrolyte Homeostasis Section, American Physiological Society

1990-1994             NIH Cardiovascular and Renal Study Section Member

1990-1996             Associate Editor, Am. J. Physiol.: Regulatory, Integrative, and Comparative Physiol.

1988                      The First Annual Young Scholar Award, The American Society of Hypertension

1984                      Harry Goldblatt Award, Council for High Blood Pressure. Research, AHA

1979                      Ernest G. Spivey Research Award, American Heart Association (AHA)

Contributions to Science (selected from >630 publications and 24 books)

Intrarenal actions of angiotensin II (Ang II) in regulating renal sodium reabsorption and blood pressure. Our studies were among the first to demonstrate the importance of the direct intrarenal actions of Ang II in regulating renal sodium reabsorption, feedback regulation of glomerular filtration rate, and long-term blood pressure. These studies also first demonstrated the powerful role of the renin-angiotensin system in controlling salt-sensitivity of blood pressure.

1. Hall JE, Guyton AC, Jackson TE, Coleman TG, Lohmeier TE, Trippodo NC. Control of glomerular filtration rate by renin-angiotensin system. Am J Physiol 1977; 233: F366-372. PMID: 920806
2. Hall JE, Guyton AC, Smith Jr MJ, Coleman TG. Chronic blockade of angiotensin II formation during sodium deprivation. Am J Physiol 1979; 237: F424-432. PMID: 391063
3. Hall JE, Guyton AC, Smith Jr MJ, Coleman TG. Blood pressure and renal function during chronic changes in sodium intake: role of angiotensin. Am J Physiol 1980; 239: F271-F280. PMID: 6254369
4. Hall JE. Control of sodium excretion by angiotensin: intrarenal mechanisms and blood pressure regulation.  Am J Physiol 1986; 250: R960-R972. PMID: 3521337

Role of kidneys and pressure natriuresis in long-term control of blood pressure and in hypertension. Our laboratory was the first to experimentally demonstrate that the kidney’s ability to excrete salt and water, via renal-pressure natriuresis, plays a crucial role in long-term control of blood pressure and in maintaining salt and water balance in several forms of hypertension.

1. Hall JE, Granger JP, Hester RL, Coleman TG, Smith Jr MJ, Cross RB. Mechanisms of "escape" from sodium retention during angiotensin II hypertension. Am J Physiol 1984; 246: F627-F634. PMID: 6720967
2. Hall JE, Granger JP, Smith Jr MR, Premen AJ. Role of renal hemodynamics and arterial pressure in aldosterone "escape". Hypertension 1984; 6 (Suppl. I): I183-I192. PMID: 6724669
3. Hall JE, Granger JP, do Carmo JM, da Silva AA, Dubinion J, George E, Hamza S, Speed J, Hall ME. Hypertension: physiology and pathophysiology. Comprehensive Physiology 2012; 2: 2393-2442. PMID:23720252
4. Hall JE. Kidney dysfunction, rather than non-renal vascular dysfunction, mediates salt-induced hypertension. Circulation 2016; 133: 894-907. PMID: 26927007

Mechanisms of obesity-induced hypertension and target organ injury. Our research demonstrated a key role for abnormal kidney function caused by intrarenal and perirenal fat, activation of mineralocorticoid receptors, and activation of the sympathetic nervous system in causing obesity-induced hypertension. We also demonstrated that obesity is associated with glomerular hyperfiltration, mitochondrial and endoplasmic reticulum dysfunction, renal injury and cardiac dysfunction even before development of severe hypertension and diabetes.

1. Hall JE. The kidney, obesity, and hypertension. Hypertension 2003; 41: 625-633. PMID: 12623970
2. Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME. Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circulation Res 2015; 116: 991-1006. PMID: 25767285
3. Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME. Obesity, kidney dysfunction and hypertension: Mechanistic links. Nature Reviews Nephrology 2019; 15: 367-385. PMID:31015582
4. Hall JE, Mouton A, da Silva AA, Omoto ACM, Wang Z, Li X, do Carmo JM. Obesity, kidney dysfunction and inflammation: interactions in hypertension. Cardiovasc Res. 2021; 117: 1859-1976. PMID: 33258945

Role of leptin in linking excess adiposity with sympathetic activation, hypertension and glucose regulation. Our lab discovered that increases in leptin, a hormone secreted by fat cells, cause chronic increases in blood pressure, providing a partial explanation for why obesity causes hypertension. Moreover, we demonstrated that leptin-induced hypertension is due to sympathetic activation. We also used genetic engineering methods to determine how fat cells communicate with the brain to differentially regulate metabolic and cardiovascular functions.

1. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998; 31: 409-414. PMID: 9453337
2. Hall JE, daSilva AA, doCarmo JM, Dubinion J, Hamza S, Munusamy S, Smith G, Stec D. Obesity-induced hypertension: role of sympathetic nervous system, leptin and melanocortins. J Biol Chem 2010; 285: 17271-17276. PMID: 20348094
3. do Carmo JM, da Silva AA, Freeman JN, Wang Z, Moak S, Stec DE, Hall JE. Role of neuronal suppressor of cytokine signaling 3 (SOCS3) in modulating chronic cardiovascular and metabolic actions of leptin. Hypertension 2018; 71: 1248-1257. PMID: 29686012
4. da Silva AA, Hall JE, Dai X, Wang Z, Salgado MC, do Carmo JM. Chronic antidiabetic actions of leptin: Evidence from parabiosis studies for a CNS-derived circulating antidiabetic factor. Diabetes 2021; 70: 2264-2274. PMID: 34344788

Heart Failure – role of central nervous system mechanisms, inflammation, and potentially new therapeutic approaches. Our lab discovered new pathways for cardiac protection mediated via the central nervous system after myocardial infarction as well as in as in obesity and hypertension. These studies are relevant to the current proposal and highlight promising new therapeutic approaches for treatment of myocardial infarction and heart failure.  

1. Mouton AJ, Li X, Hall ME, Hall JE. Obesity, hypertension and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation. Circulation Research 2020; 126: 789-806. PMID: 32163341
2. Mouton AJ, Hall JE. Novel roles of immunometabolism and non-myocyte metabolism in cardiac remodeling and injury. Am J Physiol: Reg Integ Comp Physiol 2020; 319: R476-R484. PMID: 32877243
3. Gava FN, da Silva AA, Dai X, Harmancey R, Ashraf S, Omoto ACM, Salgado M, Moak SP, Hall HE, do Carmo JM. Restoration of cardiac function after myocardial infarction by chronic activation of the CNS leptin-melanocortin system. J Am Coll Cardiology: Basic Translational Science 2021; 6: 55-70. PMID: 33532666
4. Li X, Lu Q, do Carmo JM, Wang Z, da Silva AA, Mouton A, Omoto ACM, Hall ME, Li J, Hall JE. Direct cardiac actions of the sodium glucose co-transporter 2 inhibitor empagliflozin improve myocardial oxidative phosphorylation and attenuate pressure-overload heart failure. J Am Heart Assoc 2021 Mar 16;10(6):e018298. doi: 10.1161/JAHA.120.018298. PMID: 33719499

Published Work Listed in MyBibliography:

https://www.ncbi.nlm.nih.gov/myncbi/john.hall.1/bibliography/public/